Spinach Artichoke Grilled Cheese

Featured in: Flavor Rush

Transform classic grilled cheese into a gourmet meal with a creamy spinach and artichoke filling. Fresh spinach and tender artichoke hearts combine with melted mozzarella, cream cheese, and Parmesan between buttered sourdough slices. Cooked until the bread turns golden and crispy while the cheese melts into luxurious creaminess.

This vegetarian sandwich comes together in just 25 minutes, making it ideal for a quick lunch or comforting dinner. The combination of flavors is elevated with garlic, salt, pepper, and optional red pepper flakes for a subtle kick.

Updated on Sun, 18 Jan 2026 14:10:00 GMT
Toasted sourdough slices filled with creamy spinach and artichoke, melted mozzarella oozing from the golden crust. Save
Toasted sourdough slices filled with creamy spinach and artichoke, melted mozzarella oozing from the golden crust. | fryflick.com

My neighbor knocked on my door one Tuesday holding a jar of artichoke hearts she couldn't use. I had spinach wilting in the fridge and a block of cream cheese that needed a purpose. What started as improvisation turned into something I now crave on rainy afternoons. The first bite had that perfect contrast: crisp, buttery sourdough giving way to warm, creamy filling that stretched with every pull.

I made this for my sister after she had a long week at work. She sat at my kitchen counter, exhaling for what felt like the first time in days, and didn't say a word until she finished the whole sandwich. Then she asked if I'd make it again the next time she visited. I've been making it ever since, sometimes for guests, often just for myself.

Ingredients

  • Mozzarella cheese (1 cup, 120 g, shredded): This is your melt, the cheese that stretches and holds everything together without overpowering the other flavors.
  • Cream cheese (1/2 cup, 60 g, softened): It makes the filling rich and smooth, binding the spinach and artichokes into a cohesive mixture that spreads easily.
  • Parmesan cheese (1/4 cup, 25 g, grated): A little sharpness goes a long way, adding depth without making the sandwich heavy.
  • Unsalted butter (2 tablespoons, softened): This is what turns the bread golden and crisp, so don't skip softening it first or it won't spread evenly.
  • Fresh spinach (1 cup, 30 g, chopped): Wilting it first removes excess water, which keeps your sandwich from getting soggy.
  • Artichoke hearts (1/2 cup, 80 g, canned or jarred, drained and chopped): They bring a subtle tang and meaty texture that balances the creaminess of the cheese.
  • Garlic clove (1 small, minced): Just enough to wake up the filling without overwhelming it.
  • Sourdough bread (4 slices): The slight tang and sturdy structure hold up beautifully to the filling and get perfectly crisp in the pan.
  • Salt (1/4 teaspoon): It brightens everything and helps the flavors come forward.
  • Black pepper (1/8 teaspoon, freshly ground): A little heat and sharpness to round out the richness.
  • Red pepper flakes (pinch, optional): I add them when I want a gentle warmth that sneaks up on you.

Instructions

Wilt the spinach:
Add the chopped spinach to a medium skillet over medium heat with just a splash of water. Stir it for a minute or two until it collapses and turns bright green, then drain it well and press out any extra moisture with a paper towel.
Make the filling:
In a bowl, mix the wilted spinach, chopped artichoke hearts, cream cheese, mozzarella, Parmesan, minced garlic, salt, pepper, and red pepper flakes if you're using them. Stir until everything is blended and creamy.
Assemble the sandwiches:
Spread the spinach-artichoke mixture evenly on two slices of sourdough, then top each with another slice to form sandwiches. Spread softened butter on the outside of all four bread slices.
Grill until golden:
Heat a large nonstick skillet or griddle over medium heat and place the sandwiches in the pan. Cook for 3 to 4 minutes on each side, pressing gently with a spatula, until the bread is deeply golden and the cheese inside has melted into the filling.
Serve:
Remove from the heat, slice each sandwich in half, and serve right away while the cheese is still warm and stretchy.
Spinach Artichoke Grilled Cheese served hot beside a bowl of creamy tomato soup for dipping. Save
Spinach Artichoke Grilled Cheese served hot beside a bowl of creamy tomato soup for dipping. | fryflick.com

One evening I made these sandwiches for a friend who'd just moved into a new apartment with nothing but a hot plate and a single pan. We sat on her living room floor with paper towels as plates, and she said it felt like the first real meal she'd had in weeks. It reminded me that comfort doesn't need much, just something warm and made with care.

What to Serve Alongside

A bowl of tomato soup is the obvious choice, and for good reason. The acidity cuts through the richness of the cheese, and dipping the sandwich into the soup is pure comfort. I also like a simple green salad with lemon vinaigrette or a handful of kettle chips if I'm being honest. Sometimes I'll add a pickle on the side for a little sharpness.

How to Store and Reheat

These are best eaten right away, but if you have leftovers, wrap them tightly in foil and keep them in the fridge for up to two days. Reheat in a skillet over low heat to bring back some of the crispness, or use a toaster oven if you have one. The microwave will make the bread soft and chewy, which isn't ideal but still tastes good if you're in a hurry.

Ways to Make It Your Own

I've added fresh basil to the filling when I have it, and the brightness it brings is lovely. Smoked paprika gives the whole thing a subtle warmth that feels a little more complex. You could swap the sourdough for whole wheat or even a sturdy ciabatta if that's what you have. Some people like to add sun-dried tomatoes or a handful of arugula inside for extra flavor and texture.

  • Try adding a few spoonfuls of ricotta to the filling for extra creaminess.
  • Use fontina or Gruyere instead of mozzarella if you want a nuttier, more sophisticated melt.
  • Brush the outside of the bread with olive oil instead of butter for a slightly lighter, crispier crust.
Melted cheese and wilted greens peek from crispy sourdough, highlighting this easy vegetarian Spinach Artichoke Grilled Cheese. Save
Melted cheese and wilted greens peek from crispy sourdough, highlighting this easy vegetarian Spinach Artichoke Grilled Cheese. | fryflick.com

This sandwich has become my go-to when I want something that feels special but doesn't ask much of me. I hope it brings you the same kind of quiet satisfaction it's brought me, one golden, melty bite at a time.

Recipe Guide

Can I prepare the spinach-artichoke filling ahead of time?

Yes, you can make the filling up to 2 days in advance. Store it in an airtight container in the refrigerator. When ready to assemble, spread the filling directly onto bread and cook as directed.

What bread alternatives work best for this sandwich?

Whole wheat, multigrain, brioche, or challah all work wonderfully. Avoid soft bread that may fall apart. Choose thicker slices for better structural integrity when cooking.

How do I prevent the filling from leaking out?

Spread the filling evenly, leaving a small border around the edges. Don't overstuff the sandwich. Press gently while cooking to help seal the filling between the bread slices.

Can I add meat to this sandwich?

Absolutely. Crispy bacon, prosciutto, or diced ham complement the spinach and artichoke beautifully. Add meat after spreading the filling for best flavor distribution.

What's the best way to achieve golden, crispy bread?

Use medium heat and ensure the skillet is properly preheated. Butter the outside of the bread generously and cook for 3-4 minutes per side without moving the sandwich excessively.

How should I store leftovers?

Store cooled sandwiches in an airtight container in the refrigerator for up to 2 days. Reheat in a skillet over medium-low heat to restore crispiness, or use a toaster oven.

Spinach Artichoke Grilled Cheese

Creamy spinach and artichoke filling between golden sourdough slices. A gourmet vegetarian sandwich perfect for lunch or dinner.

Prep duration
15 min
Cook duration
10 min
Complete duration
25 min
Created by Olivia Parker


Complexity Easy

Heritage American

Output 2 Portions

Dietary guidelines Meat-free

Components

Dairy

01 1 cup shredded mozzarella cheese
02 1/2 cup cream cheese, softened
03 1/4 cup grated Parmesan cheese
04 2 tablespoons unsalted butter, softened

Vegetables

01 1 cup fresh spinach, chopped
02 1/2 cup canned or jarred artichoke hearts, drained and chopped
03 1 small garlic clove, minced

Bread

01 4 slices sourdough bread

Seasonings

01 1/4 teaspoon salt
02 1/8 teaspoon freshly ground black pepper
03 Pinch of red pepper flakes, optional

Method

Phase 01

Wilt spinach: In a medium skillet over medium heat, add spinach and a splash of water. Sauté for 1-2 minutes until wilted. Drain excess moisture thoroughly.

Phase 02

Prepare filling: In a bowl, combine sautéed spinach, chopped artichoke hearts, cream cheese, mozzarella, Parmesan, garlic, salt, pepper, and red pepper flakes if using. Mix until well blended.

Phase 03

Assemble sandwiches: Spread the spinach-artichoke mixture evenly onto two slices of sourdough. Top with the remaining bread slices to form sandwiches.

Phase 04

Butter bread: Butter the outsides of all bread slices evenly.

Phase 05

Cook sandwiches: Heat a large nonstick skillet or griddle over medium heat. Place sandwiches in the skillet and cook for 3-4 minutes per side, pressing gently, until bread is golden brown and cheese is melted.

Phase 06

Finish and serve: Remove from heat, slice in half diagonally, and serve immediately.

Tools needed

  • Medium skillet
  • Mixing bowl
  • Spatula
  • Nonstick skillet or griddle
  • Knife

Allergy details

Review ingredients carefully for potential allergens and seek professional medical guidance if uncertain.
  • Contains milk: cheese and butter
  • Contains wheat: sourdough bread
  • May contain traces of soy or nuts depending on bread and cheese brands

Nutrition breakdown (per portion)

Values shown are estimates only - please consult healthcare providers for specific advice.
  • Energy: 430
  • Fats: 24 g
  • Carbohydrates: 39 g
  • Proteins: 16 g